Sen made her debut in the film Godmother, which was a critically acclaimed[by whom?] success, but her minor role may have been overlooked in favour of the protagonist, played by Shabana Azmi. She then starred in the film Daman playing Raveena Tandon’s daughter, where her small performance was appreciated.
Her breakthrough role came when she starred in the Rituparno Ghosh’s film Chokher Bali. After a few more average movies she had a critically acclaimed[by whom?] hit in 2005 with Parineeta, where she played the playmate of the film’s heroine, played by the debutante Vidya Balan. Since then she has had two more hits with the action thriller Dus and the Bengali film Antar Mahal (where she had a very small role). In 2006, she appeared in the film The Bong Connection (co-starring Shayan Munshi). In 2007, she worked in the thriller Manorama Six Feet Under with Abhay Deol. In 2011, she starred in the hit Bengali film Baishe Srabon, opposite Parambrata Chatterjee.
2014 saw Sen as the leading lady in the critically acclaimed Hrid Majharey, the first Bengali movie based on the works of William Shakespeare, and presented as a tribute on the 450th year of birth of the Bard. She co-stars with Abir Chatterjee and Indrasish Roy in this dark love-story by debutant filmmaker Ranjan Ghosh. The film has earned a rare recommendation from the very prestigious Film London in its list of world cinema based on the plays of Shakespeare. The film and its screenplay have also been included in the prestigious UGC Literature Archive. It is also famous for being the only other Bengali film after Sabuj Dweeper Raja (1979) to be shot in the Andaman and Nicobar Islands.
In 2016, she will be seen in Bollywood Diaries, a film written and directed by K.D. Satyam. The film also stars Ashish Vidyarthi and Salim Diwan.
Sen’s public profile and image is much lower-key and more demure than that of her sister Riya who has been compared more to their mother. Sen is also said to resemble her grandmother much more than either her mother or her sister. Journalists who meet her describe her as easy to talk to, and devoid of starry airs.
In an interview, she says while she enjoys Mumbai’s faster pace of life, its gyms and its nightclubs, she misses her family in Kolkata, her dog cuddles, and Kolkata’s street food, notably Jhal Muri and Aloo chaat.[17